Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Antonio

Best American Restaurants in Medical Center

Price
Regions
Areas
Top Rated
Dining Options
Seating options
Accessibility

83 restaurants available nearby

A photo of Clementine restaurant
1. Clementine
4.8
Exceptional(507)
Price: Very Expensive
• American • North Central
Booked 22 times today
Clementine, nestled in the heart of North Central, Castle Hills, offers an exquisite journey into Contemporary French/American cuisine, delighting diners with seasonal and innovative dishes. The restaurant, led by Chef John, a 2023 James Beard nominee, consistently wows with its ever-evolving menu and crowd favorites like the Ricotta Cavatelli and Clementine Crunch Bar. Guests rave about the "Feed Me" option, an adventurous five-course experience that "never disappoints" with its "multilayered flavors" and "superb" surprises. The vibrant ambiance, coupled with an expertly curated selection of wines, ensures a dining experience that is both authentic and unforgettable. Clementine truly stands out as one of San Antonio's top culinary destinations.
A photo of Alamo Biscuit Company & Panaderia restaurant
2. Alamo Biscuit Company & Panaderia
4.3
Awesome(9)
Price: Moderate
• American • Northwest
Booked 7 times today
*For reservations over 12, please contact us directly at 210-204-8520. *On the weekend, we only take reservations for parties of 6-12, for questions please contact us directly 210-204-8520.Great hospitality is an extension of great service, taking it to another level. Here at Alamo Biscuit Co., hospitality is a great dining experience that goes far beyond great food and great service. A truly great dining experience is when our guest’s needs are anticipated and met for them, resulting in 100% satisfaction. Our goal is to always strive to make every moment memorable.
A photo of Dave & Buster's - San Antonio (Balcones Heights) restaurant
3. Dave & Buster's - San Antonio (Balcones Heights)
4.6
Exceptional(105)
Price: Moderate
• American • Medical Center
Booked 22 times today
Each Dave & Buster’s has more state-of-the-art games than ever, more mouth-watering menu items and the most innovative drinks anywhere. From wings to steaks, we’ve got whatever suits your appetite and our premium bar assures we’re stocked to satisfy! Plus, you can watch your game on one of our massive HDTVs with epic stadium sound.
A photo of 54th Street Restaurant & Drafthouse - The Colonnade restaurant
4. 54th Street Restaurant & Drafthouse - The Colonnade
(0)
Price: Moderate
• American • Medical Center
54th Street was founded in Kansas City, MO by Thomas E. Norsworthy in 1989. He envisioned a place that would accommodate a consistently crowded dining room as well as a lively bar crowd, while offering the quality food and drinks that exceed national chain competitors. At 54th Street, we believe that great food starts with fresh produce, high quality meats and ingredients and meals prepared from scratch. With our amazing range of scratch prepared menu items, we truly have something for everyone. The Five-Four promise is to forever uphold our tradition of serving generous portions of housemade food and drink at an honest price. 54th Street welcomes you for all occasions. Drop in for Happy Hour with friends, celebrate a special occasion, enjoy a family night out or fly solo! Ultimately, it’s your time. Join us, experience 54 and share the 54 experience with others.
A photo of Rock & Brews - San Antonio restaurant
5. Rock & Brews - San Antonio
4.4
Awesome(17)
Price: Moderate
• American • North Central
Booked 5 times today
We have it all! American food, craft beers, signature cocktails, large parties and private dining space, live music, catering, live sports, dog-friendly patios, and more! Rock your taste buds with our American inspired menu boasting creative spins on the standards. Our menu items are prepared from scratch using fresh ingredients from the local community. Wash down our culinary creations with one of our 48+ craft beers on tap from local, national, and international breweries or check out our signature cocktails and extensive bourbon and tequila selections! The restaurant can accommodate sports fanatics and large parties of any size (including family and corporate gatherings, youth sports teams, and rehearsal dinners) in our sizable dining room or on our private patios. The restaurant also features live music, weekday lunch specials, a dog-friendly outdoor patio (ask to see our dog menu), and brunch on the weekends.
A photo of Kona Grill - North Star restaurant
6. Kona Grill - North Star
4.3
Awesome(588)
Price: Moderate
• American • North San Antonio
Booked 7 times today
Kona Grill - North Star is a sushi lover's paradise nestled in the vibrant North San Antonio area. Renowned for its "award-winning sushi," this restaurant offers an authentic Japanese dining experience with a touch of contemporary flair. The sushi menu is crafted with precision, using only the freshest ingredients, ensuring each bite is a taste revelation. The Tuna Tartar and the special traditional rolls, described as "10/10!!!" by customers, are must-tries that highlight the exceptional quality and artistry behind each dish. With a polished yet casual atmosphere and impeccable service, Kona Grill is the perfect spot for sushi enthusiasts seeking both quality and authenticity.
A photo of Red Lobster - San Antonio - NW Loop 410 restaurant
7. Red Lobster - San Antonio - NW Loop 410
4.4
Awesome(17)
Price: Moderate
• American • North San Antonio
Booked 1 time today
Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.
A photo of Pinstack - San Antonio - Park North restaurant
8. Pinstack - San Antonio - Park North
3.9
Excellent(27)
Price: Moderate
• American • Victoria
Booked 2 times today
Reservations are available in our full-service restaurant or climate-controlled patio. TO ENJOY LANE-SIDE SERVICE WHILE YOU BOWL, RESERVATIONS ARE AVAILABLE AT https://pinstackbowl.com/reserve-lane/. PINSTACK is an upscale, one-of-a-kind entertainment and dining destination. Featuring dishes from pan-seared mahi mahi to our GIANT 36-inch KingPin Pizza, everyone will enjoy eating at PINSTACK. With two fully-stocked bars, PINSTACK is a favorite spot for adults. Choose from 24 draft beers, 12 keg wines, and an extensive list of bottled wine & craft cocktails. The PINSTACK experience doesn't end after dinner! Have fun on the bowling lanes or in the game room, featuring video games, rock climbing wall, high ropes course, laser tag or bumper cars. Weekly Specials: Happy Hour |M-F 4-7 pm | $3 Domestic Pints | $5 Craft Pints | $5 House Wine | $5 House Margaritas Bowl & Bite Mondays | 4-11 pm | 1/2 Price Apps | $3 Draft Beer Wine Down Wednesdays | ALL DAY | 50% off bottles
A photo of Perry's Steakhouse & Grille - San Antonio restaurant
9. Perry's Steakhouse & Grille - San Antonio
4.7
Exceptional(9412)
Price: Expensive
• American • La Cantera
Booked 157 times today
Perry's Steakhouse & Grille - San Antonio is a beacon of authentic American cuisine nestled in the lively La Cantera area. Renowned for its "exceptional" pork chops and "outstanding" service, Perry's offers a dining experience that consistently delights locals and visitors alike. Guests rave about the "juicy, flavorful, and tender" meats, which are expertly crafted by the skilled chefs visible from the spacious, open dining area. The vibrant atmosphere, underscored by the popular Bar 79® with its floor-to-ceiling windows, enhances every visit, making Perry's a top choice for both casual and special occasions. "Perry's never disappoints," ensuring a memorable American culinary experience.
A photo of Chart House Restaurant - Tower of the Americas restaurant
10. Chart House Restaurant - Tower of the Americas
4.4
Awesome(16652)
Price: Moderate
• American • Downtown
Booked 195 times today
Chart House Restaurant - Tower of the Americas in Downtown San Antonio offers an exquisite American dining experience. Renowned for serving up fresh seafood and succulent steaks, the restaurant has been praised for its "absolutely fantastic" cuisine and service that goes "above and beyond." Guests rave about the cedar plank salmon and prime rib, describing their meals as "delicious" and "top tier." The stunning panoramic views from 750 feet in the air make dining here unforgettable. With a rich heritage of over 50 years, Chart House continues to redefine authentic American cuisine, making it a must-visit for both locals and visitors.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Our sites
Businesses
  • Delight more diners
  • Restaurant Blog
Join us on
  • Privacy Policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable International Ltd. Alphabeta Building, 14-18 Finsbury Square, London EC2A 1AH - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo