Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Antonio

Best Southwest American Restaurants in San Antonio

Price
Regions
Areas
Top Rated
Dining Options
Seating options
Accessibility

69 restaurants available nearby

A photo of Supper restaurant
1. Supper
4.6
Exceptional(3166)
Price: Expensive
• Mexican • Downtown
Booked 24 times today
Supper, nestled in the heart of Downtown San Antonio, offers an exceptional Contemporary American dining experience that embodies the essence of South Texas hospitality. Housed in the historic and charming Hotel Emma, Supper is celebrated for its "phenomenal food service and ambiance." Diners rave about the "inventive seasonal cocktails" and the meticulously crafted dishes such as the "country fried quail" and "mushroom risotto," which are consistently lauded as "out of this world." The restaurant's commitment to quality is evident, with one guest noting, "the food and service were beyond phenomenal!" Whether it's a special occasion or a casual meal, Supper's vibrant atmosphere and culinary excellence make it a standout destination for Contemporary American cuisine.
A photo of Southerleigh Fine Food & Brewery restaurant
2. Southerleigh Fine Food & Brewery
4.8
Exceptional(3101)
Price: Moderate
• Mexican • Downtown
Booked 41 times today
Southerleigh Fine Food & Brewery in downtown San Antonio masterfully celebrates Southern cuisine with a modern twist. Helmed by Chef Jeff Balfour, whose Galveston roots shine through in dishes like the "BEST shrimp boil entree in town!" and the mouth-watering crab mac and cheese, which has been called "the bomb." Diners rave about the "excellent service" and "fun environment," with specialties such as the jalapeño cornbread and crispy, juicy fried chicken consistently earning high praise. Located in the historic Pearl brewhouse, Southerleigh not only offers a delectable menu but also brews its own beer, providing a uniquely Southern experience that is both innovative and deeply rooted in tradition.
A photo of Domingo Restaurante restaurant
3. Domingo Restaurante
4.5
Awesome(785)
Price: Expensive
• Mexican • Downtown
Booked 86 times today
Join us in our open-air restaurant on the Historic San Antonio River Walk with a natural ambiance where curated contemporary art intersects with a historical setting. Domingo's menus offer the flavors of South Texas and an agave-forward beverage program celebrating the culture of San Antonio with modern culinary flair.
A photo of Chart House Restaurant - Tower of the Americas restaurant
4. Chart House Restaurant - Tower of the Americas
4.5
Awesome(16570)
Price: Moderate
• Mexican • Downtown
Booked 145 times today
Dine in the heart of Downtown San Antonio at Chart House Restaurant, a haven of American cuisine that promises more than just a meal. Celebrated for both its culinary prowess and enchanting views, Chart House offers an array of finely-crafted American dishes, from fresh fish specialties to the sumptuous slow-roasted prime rib. Guests rave about the "delicious food and great service," with highlights including the "best key lime pie ever" and an original Hot Chocolate Lava Cake that perfectly concludes a memorable dining experience. Whether it's the stunning city vistas or the "exceptional service," Chart House provides a dining experience that consistently delights and surprises, making it a must-visit for locals and tourists alike.
A photo of Bohanan's Prime Steaks and Seafood restaurant
5. Bohanan's Prime Steaks and Seafood
4.8
Exceptional(8259)
Price: Very Expensive
• Mexican • Downtown
Booked 55 times today
Bohanan's Prime Steaks and Seafood in downtown San Antonio is a gastronomic landmark where the allure of tender, prime beef and fresh seafood create a perfect dining experience. Known for its mesquite-grilled steaks like the "spectacular" Akaushi beef, Bohanan’s also boasts a AAA Four Diamond rating and a Wine Spectator’s Best of Award of Excellence. Diners rave about the "perfect steak doneness" and "spectacular table-side desserts flambé." The ambiance, set in a historic building near the River Walk, adds to its charm, making every visit memorable. It’s no wonder guests say, "Bohanan’s is consistently the best service in the city," making it a must-visit for anyone seeking the quintessential steakhouse experience.
A photo of Mezquite restaurant
6. Mezquite
4.5
Awesome(197)
Price: Moderate
• Mexican • Downtown
Booked 41 times today
Nestled in the heart of Downtown San Antonio, Mezquite is a culinary gem that brings the vibrant flavors of the Sonoran region to life. Diners rave about the authenticity and quality of the cuisine, with one guest exclaiming, "The food and everything was beyond great!! Can’t wait to come back! Congratulations!" From the grilled meats and house-made flour tortillas to the exquisite cocktails, each dish is a celebration of tradition with a modern twist. The ambiance, whether on mariachi nights or a regular evening, enhances the dining experience, making every visit memorable. Whether it's the "life-changing" Elotes or the "divine" Carne Asada quesadilla, Mezquite stands out as a top destination for Mexican/Southwestern cuisine in San Antonio.
A photo of Boiler House at Pearl restaurant
7. Boiler House at Pearl
4.7
Exceptional(2104)
Price: Expensive
• Mexican • Downtown
Booked 22 times today
Nestled in the historic Pearl Brewery complex in Downtown San Antonio, Boiler House at Pearl stands as a beacon of exceptional Steakhouse cuisine. With a focus on "Texas ranch-style" dishes, Executive Chef Alberto "Beto" Gutierrez masterfully crafts grilled specialties using only the finest ingredients sourced from local farms. Patrons rave about the perfection of their steaks, with one guest exclaiming, "One of the best steaks I have had!" Complemented by a vibrant atmosphere and a meticulously curated wine list offered at unbeatable prices, the Boiler House promises not only a meal but an experience. As an added bonus, the outdoor patio provides a perfect backdrop for al fresco dining along the scenic River Walk, making it a must-visit destination for both locals and visitors.
A photo of Isidore restaurant
8. Isidore
4.6
Exceptional(88)
Price: Very Expensive
• Mexican • Downtown
Booked 20 times today
Nestled in the heart of Downtown San Antonio, Isidore is a culinary gem renowned for its exquisite fine cuts and vibrant atmosphere. Patrons rave about the "perfectly prepared" shareable ribeye and the "beyond fantastic" Wagyu Ribeye, which comes with uniquely sauced potatoes that are a must-try. The authenticity and mastery of fine cuts at Isidore are evident, with one diner describing their experience as "probably the best restaurant in San Antonio." The intimate décor and robust wine list complement the high-quality meats, making Isidore the ideal spot for a celebration or a luxurious night out. Join the chorus of delighted guests and indulge in a fine cuts cuisine that truly stands out at Isidore.
A photo of Brenner's on the River Walk restaurant
9. Brenner's on the River Walk
4.7
Exceptional(313)
Price: Moderate
• Mexican • Downtown
Booked 41 times today
Brenner's on the River Walk in downtown San Antonio offers a quintessential American dining experience, combining tradition and elegance with a stunning three-story dining room overlooking the river. A continuation of the Brenner's legacy since 1936, this restaurant excels in crafting classic American dishes, especially its steaks which are often described as "cooked to perfection" and are a highlight among diners. Reviewers rave about the "amazing food amazing atmosphere" and the personalized service that makes each visit memorable. One guest mentioned, "The steak was flavorful and cooked to perfection," underscoring the restaurant's commitment to quality. Whether it's for a casual dinner or a special occasion, Brenner’s on the River Walk is celebrated for its exceptional American cuisine and vibrant ambiance, making it a must-visit culinary destination in San Antonio.
A photo of Seasons 52 - San Antonio restaurant
10. Seasons 52 - San Antonio
4.8
Exceptional(692)
Price: Expensive
• Mexican • Alamo Heights
Booked 55 times today
Seasons 52 in Alamo Heights, San Antonio, epitomizes the essence of American cuisine with its ever-evolving seasonal menu that captures the freshness and vibrancy of local ingredients. Praised for its "exceptional food and service," this gem offers dishes that are oak-fire grilled or brick oven roasted, highlighting the natural flavors without the need for a fryer. The ambiance complements the quality of the meals, with guests celebrating everything from casual dining to special occasions, consistently noting the "great food and friendly service, as always!" Whether it's the cedar plank salmon or the innovative wine list, Seasons 52 delivers a top-notch American dining experience, making every visit memorable.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Our sites
Businesses
  • Delight more diners
  • Restaurant Blog
Join us on
  • Privacy Policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable International Ltd. Alphabeta Building, 14-18 Finsbury Square, London EC2A 1AH - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo