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Best Southern American Restaurants in Mission District

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139 restaurants available nearby

A photo of Curio restaurant
1. Curio
4.3
Awesome(309)
Price: Moderate
• Southern american • Mission
Booked 5 times today
Curio, located in the vibrant Mission District of San Francisco, offers an exceptional Contemporary American dining experience. This eclectic bar and restaurant skillfully merges regional American cuisine with a flair for the unconventional, creating a menu that delights and surprises. Reviewers rave about the “unique and flavorful” dishes, highlighting the perfectly cooked burgers and tender braised short ribs. The atmosphere is enriched by “awesome cocktails and food,” along with live music that elevates the dining experience. With excellent service and a seamless connection to the neighboring venue, The Chapel, Curio ensures a memorable night filled with culinary and cultural pleasures.
A photo of House of Prime Rib restaurant
2. House of Prime Rib
4.8
Exceptional(16010)
Price: Very Expensive
• Southern american • Civic Center / Hayes Valley / Van Ness
Booked 189 times today
House of Prime Rib in San Francisco is a beacon of authentic American cuisine, renowned for its "iconic" status and exceptional prime rib. With 62 years of unwavering dedication, it’s no surprise that this establishment garners glowing praise from loyal patrons who rave about its "festive" atmosphere and "superb" service. Guests continually highlight the "delicious" prime rib, which is described as "massive" and "perfectly cooked," making every visit a memorable experience. The lively ambiance and the meticulous attention from the staff ensure that every meal feels like a special occasion. Truly, House of Prime Rib offers a quintessential American dining experience.
A photo of Tartine Manufactory - San Francisco restaurant
3. Tartine Manufactory - San Francisco
4.6
Exceptional(1042)
Price: Expensive
• Southern american • Mission
Booked 18 times today
Tartine Manufactory in San Francisco’s vibrant Mission District is a beacon of authentic American cuisine, celebrated for its mastery of artisanal bread and world-class sourdough pizza. Diners rave about the restaurant’s "outstanding" food and "fantastic" service, emphasizing the quality of its market-driven, seasonal menu. The pizzas, described as "some of the best in the city," showcase a true American culinary flair with unique toppings and a perfect crust. The atmosphere is equally inviting, with a "lovely, airy space" and a laid-back vibe that makes every visit a special occasion. Tartine Manufactory is a must-visit for anyone craving genuine American flavors.
A photo of Fable - SF restaurant
4. Fable - SF
4.6
Exceptional(2219)
Price: Moderate
• Southern american • Castro
Booked 25 times today
Nestled in the heart of San Francisco's vibrant Castro neighborhood, Fable - SF is a true gem for Contemporary American cuisine lovers. The restaurant’s seasonal California dishes are hailed as "delicious" and "scrumptious," promising an authentic taste of contemporary culinary artistry. The charming garden patio, often described as "gorgeous" and "beautiful," offers a unique outdoor dining experience that perfectly complements the exquisite dishes. With friendly and efficient staff, Fable ensures a warm and inviting atmosphere where every meal feels like a special occasion. Whether you're enjoying brunch or dinner, Fable's commitment to quality and freshness makes it an unforgettable dining destination.
A photo of Frances restaurant
5. Frances
4.8
Exceptional(3681)
Price: Very Expensive
• Southern american • Castro
Booked 21 times today
Frances, nestled in the heart of The Castro in San Francisco, is a beacon of Contemporary American cuisine, celebrated for its vibrant and innovative dishes. Chef Melissa Perello’s seasonal menu masterfully showcases "California Cuisine," emphasizing fresh, locally sourced ingredients that "speak for themselves." Diners rave about the "phenomenal" short rib and "divine" house sourdough, noting the harmonious blend of flavors that elevate each dish. The restaurant’s ambiance is described as cozy yet elegant, making it a perfect spot for special occasions. With its "exemplary" service and carefully curated wine pairings, Frances offers an unforgettable dining experience that keeps patrons returning for more.
A photo of The Progress restaurant
6. The Progress
4.8
Exceptional(2527)
Price: Very Expensive
• Southern american • Western Addition
Booked 46 times today
The Progress in Western Addition, San Francisco, offers a truly remarkable Californian dining experience. Celebrated for its "innovative menu" and "delicious flavors," this restaurant uses entirely local ingredients to craft dishes that highlight the essence of Californian cuisine. Guests rave about the duck, described as a "must-try" and "100% juicy and tender," alongside other inventive dishes like the seaweed noodles and Tierra vegetables masa dumplings. The ambiance is "casual and playful," providing the perfect setting for what many reviewers describe as "the best meal in SF." With excellent service and a creative menu, The Progress is an unmissable culinary gem.
A photo of State Bird Provisions restaurant
7. State Bird Provisions
4.7
Exceptional(3316)
Price: Very Expensive
• Southern american • Western Addition
Booked 75 times today
State Bird Provisions in Western Addition, San Francisco, offers an extraordinary American dining experience that truly stands out. Known for its inventive "dim sum" style service, this restaurant presents a creative twist on classic American flavors. Diners rave about the "delicious, innovative, and surprising" small dishes that keep the experience fresh and exciting. With impeccable service and a lively atmosphere, patrons find themselves returning for more. The signature quail dish and the adventurous blue corn-pepita pancakes with braised bacon and coffee butter are must-tries. As one enthusiastic diner put it, "Every dish was like culinary viagra," making this a must-visit for any American cuisine enthusiast.
A photo of Starbelly restaurant
8. Starbelly
4.6
Exceptional(1604)
Price: Moderate
• Southern american • Castro
Booked 43 times today
Starbelly in The Castro serves an exceptional Californian cuisine experience that has diners raving about its “consistently delicious food and cocktails” and “warm, helpful, and personable” service. This urban gem brings Californian comfort food to life with a seasonal menu that harmonizes perfectly with their craft cocktails, beer, and wine. Diners can enjoy dishes like the popular corn pizza and fresh pasta amidst a lively ambiance, often described as “an oasis in the heart of the city.” The charming garden patio adds a special touch, making Starbelly a vibrant neighborhood favorite perfect for any occasion.
A photo of Firefly Restaurant restaurant
9. Firefly Restaurant
4.9
Exceptional(3050)
Price: Expensive
• Southern american • Noe Valley
Booked 45 times today
Firefly Restaurant in Noe Valley, San Francisco, is a shining beacon of authentic American cuisine. With its innovative and ever-evolving menu, Firefly delivers "mind blowing" dishes that perfectly capture the essence of American flavors while catering to diverse palates. Known for its "delicious, healthy, perfectly portioned" offerings, this neighborhood gem consistently delights diners with its creative combinations, including standout dishes like fried chicken and Brussel sprouts. The cozy, welcoming atmosphere, combined with a "warm, efficient" service, ensures a memorable dining experience. Firefly truly embodies the heart and soul of American dining, making it a must-visit destination for food enthusiasts.
A photo of The Palm Court at RH San Francisco restaurant
10. The Palm Court at RH San Francisco
4.8
Exceptional(1850)
Price: Very Expensive
• Southern american • Potrero Hill / Dogpatch
Booked 82 times today
The Palm Court is located in RH San Francisco's Gallery at the Historic Bethlehem Steel Building. Recalling the distinctive glamour of San Francisco's Gilded Age, the stunning statement space is sheathed in Italian Calacatta gold marble and features a cascading center fountain, towering Medjool date palms and glimmering chandeliers. Adjacent to the restaurant, two luminous wine bars offer exceptional wines and Champagnes from around the world.For group dining inquiries, please email: sfhospitality@rh.com
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • Melody
    San Francisco Bay Area •5 reviews
    5.0
    Dined 3 days ago
    It was the perfect date night spot. I came here solo and enjoyed a feast! The staffs are super attentive and service was beyond expectations. Food was very unique for a southern charm and taste great!
    More info
    PreludePrice: Expensive• Californian• Financial District / Embarcadero
    •
    4.7
  • JeannieVIP
    San Francisco Bay Area •31 reviews
    5.0
    Dined 5 days ago
    This place is full of heartwarming flavors of Southern comfort food. Definitely a neighborhood gem. Every bite feels like a warm hug from home. The menu was full of classic favorites and the service team was friendly and attentive. They checked in with us often, perhaps a bit too often however, their dedication was not disappointing. The atmosphere strikes the perfect balance of kindness and wit, offering a welcoming space for laughter and great conversation. It’s the kind of place where delicious food meets delightful company, making our visit a memorable one. The corn muffins are out of this world, adding butter and honey. The fried chicken was crispy, moist and flavorful on the inside. BBQ pull pork sandwich was perfect, tender, tangy and sweet. Side dishes were macaroni & cheese and collard greens, prepared just right. Parking can be a challenge, street and meter parking. They accept reservations through OpenTable.
    More info
    Hard Knox Cafe on Clement StreetPrice: Moderate• Regional American (Southern)• Richmond District
    •
    4.9
  • Angel
    San Francisco Bay Area •1 review
    5.0
    Dined on 2 Mar 2025
    It was my first time there. Great intimate setting. Everyone was super friendly. My only suggestion would be. Because of the name biscuits and blues… The biscuit other than the entertainment needs to be the star!
    More info
    Biscuits and BluesPrice: Expensive• Regional American (Southern)• Downtown / Union Square
    •
    4.7

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