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Diego's Cantina, University City, MO

Diego's Cantina

4.6
4.6
470 Reviews
$30 and under
Mexican

Make a booking

2 people
19:00
Booked 4 times today
  • Charming
  • Great for creative cocktails
  • Great for outdoor dining
Owned and operated by Natasha Kwan, St. Louis Post Dispatch's Best Chef in St. Louis, our elevated Mexican restaurant blends vibrant flavors with a tropical atmosphere that feels like a vacation, taking you far from St. Louis. We’re located in a charming University City neighborhood, just steps from Clayton.

Our menu features plates like queso flameado, costra and crunch tacos, enchiladas, nachos and a few Tex-Mex options. Cocktails and margaritas are crafted with fresh-squeezed juices and premium ingredients.


We offer all-day happy hour Tuesday through Thursday. We also accommodate parties of 10 or more for special celebrations.

Other accolades:
Best New Restaurant, A-List Restaurant (St. Louis Magazine)
Best Queso (Ian Froeb of St. Louis Post-Dispatch)

To Note:
Gluten free friendly - our fryer is dedicated gluten free so eat all the chips you want!
Many vegan options
Dog friendly patio and sidewalk

Order delivery or takeout

Dining areas

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Hours of Operation
    Fri, Sat 12:00–22:00 Bar Tue–Thu 16:00–22:00 Fri, Sat 12:00–23:00 Dinner Tue–Thu 16:00–21:00
  • Phone number
    (314) 553-9906
  • Payment Options
    AMEX, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Executive Chef
    Natasha Kwan
  • Area
    University City
  • Cross Street
    Delmar
  • Parking details
    Street Parking
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeaway, Vegan, Wheelchair Access, Wine

What 470 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.6
4.6 based on recent ratings
  • 4.5Food
  • 4.6Service
  • 4.8Ambience
  • 4.3Value

NoiseModerate

Loved For

  • St. Louis

    Child-friendly

  • St. Louis

    Innovative

  • St. Louis

    Healthy

  • St. Louis

    Neighbourhood gem

  • St. Louis

    Great for outdoor dining

  • St. Louis

    Lively

  • Midtown

    Best Ambience

  • Midtown

    Innovative

  • Midtown

    Good for groups

  • Midtown

    Healthy

  • Midtown

    Neighbourhood gem

  • Midtown

    Great for outdoor dining

  • Midtown

    Romantic

  • Midtown

    Lively

Review summary

AI-generated from verified diner reviews
Diego's Cantina offers a "fresh and delicious" twist on Mexican cuisine. Guests rave about the "best queso," "fantastic mezcal margaritas," and a gluten-friendly menu. The vibrant atmosphere and "coolest decor in town" enhance the dining experience. Service is generally friendly, though experiences may vary.

470 Reviews
  1. Marc

    Kansas City

    21 reviews

    vip
    5.0

    21 reviews

    Dined on 2 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    I have gone many times. The restaurant never disappoints. Servers are terrific. They are the perfect mix of friendly, professional, and helpful. The food taste really good always seems freshly prepared. The heat throughout the food seems very consistent so I doubt they use a microwave or other to reheat food—if I am wrong they are best reheaters there ever were! Atmosphere is just right. Enjoyable casual and prices in today’s world are pretty darn good! Highly recommend

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  2. Laurie

    St. Louis

    1 review

    5.0

    1 review

    Dined on 2 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious and fresh twist on Mexican food in a lovely location. Recommend!

    Is this helpful?

  3. James

    Dallas

    1 review

    5.0

    1 review

    Dined on 25 October 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious food and drinks at really good prices. Lots of healthy and vegetarian options as well. Will definitely be going back.

    Is this helpful?

  4. Mayte

    Memphis

    35 reviews

    vip
    5.0

    35 reviews

    Dined on 25 October 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Great space for a large party. Great service and good!

    Is this helpful?

  5. Haley

    St. Louis

    4 reviews

    vip
    4.0

    4 reviews

    Dined on 24 October 2024

    1. Overall 4
    2. Food 5
    3. Service 1
    4. Ambience 5
    The food is always delicious! There were seven of us and a 20% gratuity was automatically added to our check. which we all kind of were irritated about because we were not told ahead of time. She also could not split up our check. We waited about 40 minutes to order dessert and then another 30 minutes to actually get our checks. It seems like there was one person, seating tables, taking orders, and bringing the food out. Food is delicious. They need more staff

    Is this helpful?

  6. Robin

    Raleigh

    14 reviews

    vip
    5.0

    14 reviews

    Dined on 28 September 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Truly delicious food! The margaritas were top notch!! Beautiful restaurant, tastefully decorated without being kitschy. Would definitely return!

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  7. Brendan

    Washington DC

    1 review

    5.0

    1 review

    Dined on 21 September 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food with lots of options. The service was good too.

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  8. Elin

    St. Louis

    16 reviews

    5.0

    16 reviews

    Dined on 19 September 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Me and my friends come here once every couple months for a girls night and it never disappoints. The service is always great. The food is always great. The ambience is always great. Thank you!

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  9. Andrew

    St. Louis

    29 reviews

    3.0

    29 reviews

    Dined on 6 September 2024

    1. Overall 3
    2. Food 3
    3. Service 3
    4. Ambience 4
    Disappointed. We’ve been before and it was great. But this time, the server had trouble entering the order in the machine. And the food was just…meh. Not worth the $40 per person - food/drinks.

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  10. Elin

    St. Louis

    16 reviews

    5.0

    16 reviews

    Dined on 31 August 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food and margaritas! The grilled cheese with chicken taco is my favorite!

    Is this helpful?

FAQs

Diego's Cantina offers takeout which you can order by calling the restaurant at (314) 553-9906.

Diego's Cantina is rated 4.6 stars by 470 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
19:00
Booked 4 times today

Order delivery or takeout

Google Map for Diego's Cantina

630 North & South Road, University City, MO 63130

Dining areas

Additional information

  • Cross Street
    Delmar
  • Area
    University City
  • Hours of Operation
    Fri, Sat 12:00–22:00 Bar Tue–Thu 16:00–22:00 Fri, Sat 12:00–23:00 Dinner Tue–Thu 16:00–21:00
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Dining style
    Casual Dining
  • Dress code
    Casual Dress
  • Parking details
    Street Parking
  • Payment Options
    AMEX, Discover, Mastercard, Visa
  • Executive Chef
    Natasha Kwan
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeaway, Vegan, Wheelchair Access, Wine
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