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Diego's Cantina, University City, MO

Diego's Cantina

4.4
4.4
480 Reviews
$30 and under
Mexican
  • Neighbourhood gem
  • Lively
  • Charming
Owned and operated by Natasha Kwan, St. Louis Post Dispatch's Best Chef in St. Louis, our elevated Mexican restaurant blends vibrant flavors with a tropical atmosphere that feels like a vacation, taking you far from St. Louis. We’re located in a charming University City neighborhood, just steps from Clayton.

Our menu features plates like queso flameado, costra and crunch tacos, enchiladas, nachos and a few Tex-Mex options. Cocktails and margaritas are crafted with fresh-squeezed juices and premium ingredients.


We offer all-day happy hour Tuesday through Thursday. We also accommodate parties of 10 or more for special celebrations.

Other accolades:
Best New Restaurant, A-List Restaurant (St. Louis Magazine)
Best Queso (Ian Froeb of St. Louis Post-Dispatch)

To Note:
Gluten free friendly - our fryer is dedicated gluten free so eat all the chips you want!
Many vegan options
Dog friendly patio and sidewalk

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Unfortunately, this restaurant is not on the OpenTable booking network. To check availability, please contact them directly.

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Dining areas

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Hours of Operation
    Fri, Sat 12:00–22:00 Bar Tue–Thu 16:00–22:00 Fri, Sat 12:00–23:00 Dinner Tue–Thu 16:00–21:00
  • Phone number
  • Payment Options
    AMEX, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Executive Chef
    Natasha Kwan
  • Delivery & takeout
  • Area
    University City
  • Cross Street
    Delmar
  • Parking details
    Street Parking
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeaway, Vegan, Wheelchair Access, Wine

What 480 people are saying

Overall ratings and reviews

4.4
4.4 based on recent ratings
  • 4.3Food
  • 4.3Service
  • 4.5Ambience
  • 4.2Value

NoiseModerate

Review summary

AI-generated from verified diner reviews
Diego's Cantina offers a delightful Mexican dining experience with "great margaritas," a cozy atmosphere, and attentive service. Highlights include "delicious shrimp fajita bowls," a refreshing vegan menu, and a "fantastic grilled cheese shell taco." While some dishes vary in flavor, the restaurant's vibrant decor and "superb service" make it a must-visit.
480 Reviews
  1. Gianna

    Los Angeles1 review

    4.0

    Dined on 23 February 2025

    1. Overall 4
    2. Food 3
    3. Service 3
    4. Ambience 4
    our first server was bad, but our second server was amazing!!!

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  2. Darla

    St. Louis5 reviews

    3.0

    Dined on 14 February 2025

    1. Overall 3
    2. Food 2
    3. Service 5
    4. Ambience 4
    When I made the reservation for a high table, I guess I did not realize I would be sitting right next to the entrance of the restaurant. The margarita I had had too much lime flavor in it. The shredded chicken in my burrito was dry. Staff was exceptional by being very attentive and polite! 

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  3. Emily

    San Diego1 review

    3.0

    Dined on 8 February 2025

    1. Overall 3
    2. Food 2
    3. Service 3
    4. Ambience 4
    Margaritas were fantastic, food was just ok. Chicken birria taco was disappointing.

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  4. Heather

    St. Louis1 review

    5.0

    Dined on 22 January 2025

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 4
    Great place to go for decent food, especially if there are vegetarians in your party.

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  5. Lucie VIP

    St. Louis7 reviews

    5.0

    Dined on 3 January 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Best fish tacos! Great atmosphere & service. Margs great too!!

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  6. Indira

    St. Louis1 review

    5.0

    Dined on 1 January 2025

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 4
    Went in New Year’s Eve. The ambience was very nice. The waiter was attentive and professional. The food came out quickly and was delicious.

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  7. Shawn

    St. Louis1 review

    5.0

    Dined on 29 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The Food, Service, and Overall Experience 10/10. I highly recommend the shrimp fajita bowl. Delicious!! It was our first visit, and we will definitely be back!!!

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  8. Sarah

    St. Louis7 reviews

    3.0

    Dined on 25 December 2024

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    The margaritas were very good but the food was only OK. However the decor and service were great. There are other more affordable Mexican restaurants with more menu options close by; I think I'll stick to them in the future.

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  9. Charles Hoffman VIP

    St. Louis40 reviews

    5.0

    Dined on 20 December 2024

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 3
    More authentic Mexican than most. Service was outstanding as usual. Comfortable, friendly place.

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  10. Lewis

    St. Louis1 review

    5.0

    Dined on 27 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious food that makes vegan dishes taste great for a non-vegan eater! fresh twist on Mexican food in a lovely location. Recommend!

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FAQs

Diego's Cantina offers takeout which you can order by calling the restaurant at (314) 553-9906.

Diego's Cantina is rated 4.4 stars by 480 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Not available on OpenTable

Unfortunately, this restaurant is not on the OpenTable booking network. To check availability, please contact them directly.

Is this your restaurant?
Claim this listing
Google Map for Diego's Cantina

630 North & South Road, University City, MO 63130

Dining areas

Additional information

  • Cross Street
    Delmar
  • Area
    University City
  • Hours of Operation
    Fri, Sat 12:00–22:00 Bar Tue–Thu 16:00–22:00 Fri, Sat 12:00–23:00 Dinner Tue–Thu 16:00–21:00
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Dining style
    Casual Dining
  • Dress code
    Casual Dress
  • Parking details
    Street Parking
  • Payment Options
    AMEX, Discover, Mastercard, Visa
  • Executive Chef
    Natasha Kwan
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeaway, Vegan, Wheelchair Access, Wine
  • Delivery & takeout
  • Privacy Policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
  • Cookie Preferences
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