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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
465 Reviews
$50 and over
Seafood

Make a booking

2 people
19:00
Booked 12 times today
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

What 465 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.7Ambience
  • 4.4Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Innovative

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience with "innovative, fresh" dishes and "excellent" service. The restaurant's ambiance, located in the Mayo Clinic, is both "lovely" and "relaxing." Diners rave about the "fantastic" meals, including monthly special dinners and wine pairings. It's a "hidden gem" worth discovering.

465 Reviews
  1. Brenda

    VIP

    Jacksonville

    78 reviews

    5.0

    78 reviews

    Dined today

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The evening could not have been better. Our hat is off to the staff and the food. It is so nice to dine somewhere you can actually have a conversation with having to raise your voice and keep asking people to repeat what they said. HIghly recommend this “hidden” jewel.

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  2. Tracy

    New Jersey

    4 reviews

    5.0

    4 reviews

    Dined today

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent dinner-food, atmosphere, and service! Our waitress, Kaely was attentive and helpful! This is def a hidden gem!

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  3. Harrell

    Jacksonville

    4 reviews

    3.0

    4 reviews

    Dined 1 day ago

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    Sea bass needed a vegetable side. I would describe Potato wedges with ribeye as a failed test. Dry seasoning on them was bad.

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  4. Bunnie

    VIP

    Jacksonville

    5 reviews

    5.0

    5 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Celebrating a friends Birthday was a perfect evening. Staff very attentive, professional and friendly. Food and wine was a 10 ++
    M Brothers at MayoResponded 1 day ago
    Thank you for celebrating with us! We’re thrilled to hear you had a perfect evening with attentive service and incredible food and wine. Hope to see you again soon! 🥂✨

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  5. Chris

    VIP

    Jacksonville

    54 reviews

    5.0

    54 reviews

    Dined on 24 December 2024

    1. Overall 5
    2. Food 5
    3. Service 3
    4. Ambience 5
    everything was great last night--food was excellent and drinks were wonderful only problem was the server was sniffling and coughing and sneezing from the first time she came to wait on us so that was an issue that needs corrected
    M Brothers at MayoResponded 6 days ago
    Thank you for your feedback and for dining with us. We're glad you enjoyed the food and drinks! We sincerely apologize for the issue with the server and will address it to ensure a better experience in the future.

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  6. Anne

    VIP

    Chicago

    8 reviews

    5.0

    8 reviews

    Dined on 24 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    It was a treat to have a nice lunch (with wine!) during a day of medical appointments. Food was delicious and Douglas was a terrific server. We’ll be back!
    M Brothers at MayoResponded 6 days ago
    Thank you for joining us for lunch! We're delighted you enjoyed the food (and wine!) and appreciated Douglas's terrific service. We look forward to seeing you again soon!

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  7. Mary

    VIP

    New York City

    47 reviews

    5.0

    47 reviews

    Dined on 21 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous dinner. Service was excellent We did the Japan dinner with wine pairings. Looking forward to the next one.
    M Brothers at MayoResponded on 23 December 2024
    Thank you for joining us for the Japan dinner! We’re thrilled you enjoyed the fabulous meal and wine pairings. Can’t wait to see you at the next one! 🍷🍣

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  8. Julie

    VIP

    Jacksonville

    14 reviews

    5.0

    14 reviews

    Dined on 18 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Can I tell you how happy I am to get a Medure/Matthew's quality meal without having to suffer through the PV or downtown traffic? Douglas, our server, was so friendly and personable. It took a moment to adjust to eating a fine meal in a hospital, but it really was fantastic. We had the calamari, French onion soup, tonight's sea bass special, and the filet. All fantastic!!! Highly recommend!
    M Brothers at MayoResponded on 23 December 2024
    Thank you for the wonderful review! We're thrilled you enjoyed a Medure/Matthew's quality meal without the traffic. Douglas will be so pleased to hear your kind words! It’s great to know the atmosphere grew on you and that each dish exceeded expectations. We truly appreciate the recommendation and hope to see you again soon! 🍴✨

    1 person found this helpful

  9. Laurie

    Jacksonville

    1 review

    5.0

    1 review

    Dined on 9 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Many people stopped by to say hello. They knew us and were friendly. Our server, Jordan, went above and beyond to care for us.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your kind words! We're thrilled to hear that Jordan and our team made you feel so welcome. We look forward to hosting you again soon! 😊🍴

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  10. GEORGE

    Charleston

    10 reviews

    2.0

    10 reviews

    Dined on 3 December 2024

    1. Overall 2
    2. Food 2
    3. Service 4
    4. Ambience 2
    I Had lunch numerous time there and was very happy first time dinner there the food was over cooked and dry mostly fried calamari French onion soup and triple tail fish of the day Very cafeteria style taste and donneness Very disappointed
    M Brothers at MayoResponded on 12 December 2024
    We're sorry to hear about your dinner experience and appreciate your feedback. This isn’t the standard we strive for, and we’ll address it with our team. We hope you’ll give us another chance to impress you.

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 465 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
19:00
Booked 12 times today
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
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