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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
454 Reviews
$50 and over
Seafood

Make a booking

2 people
19:00
Booked 14 times today
Experiences are available.
  • Good for business meals
  • Innovative
  • Good for special occasions
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • 11/23 Morocco "Grows Together/Goes Together"

    US$90.00 - US$135.00 per person

    23 Nov 2024 only
    Join us at M Brothers on Saturday, November 23, 2024, for an unforgettable culinary experience! Indulge in a 4-course tasting menu inspired by the vibrant flavors of Morocco! This experience is priced at $90 per person, or elevate your experience with wine pairings for each course for $135. This special menu will ONLY be available November 23rd.
    11/23 Morocco "Grows Together/Goes Together" photo
  • 12/21 Japan "Grows Together/Goes Together"

    US$90.00 - US$135.00 per person

    21 Dec 2024 only
    Join us at M Brothers on Saturday, December 21, 2024, for an unforgettable culinary experience! Indulge in a 4-course tasting menu inspired by the vibrant flavors of Japan! This experience is priced at $90 per person, or elevate your experience with wine pairings for each course for $135. This special menu will ONLY be available December 21st.
    12/21 Japan "Grows Together/Goes Together" photo

What 454 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.6Ambience
  • 4.4Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Best Overall

  • Jacksonville / Northeast Florida

    Best Service

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville / Northeast Florida

    Healthy

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Best Service

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience right in the heart of Mayo Clinic. Guests rave about the "outstanding" food and service, praising the innovative menu and accommodating staff. The ambiance is both calming and inviting, making it a "hidden gem" for any occasion. A must-visit!

454 Reviews
  1. Helen

    London

    37 reviews

    vip
    5.0

    37 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Dining at M Brothers is consistently great! Food is always delicious and perfectly prepared. The menu is filled with things we enjoy eating. And it is all served and delivered by your delightful team. Destiny is a worthy and engaging ambassador. I always look forward to seeing her. Makes the experience that much more special. M Brothers is a true gem.

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  2. Margaret

    Calgary

    3 reviews

    vip
    5.0

    3 reviews

    Dined 3 days ago

    1. Overall 5
    2. Food 5
    3. Service 3
    4. Ambience 4
    Wonderful food!! So convenient to have an outstanding and high quality restaurant at Mayo.

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  3. Cristina

    Jacksonville

    1 review

    4.0

    1 review

    Dined 4 days ago

    1. Overall 4
    2. Food 5
    3. Service 4
    4. Ambience 3
    Risotto special was amazing !!!! Service was great. Amazing homemade bread

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  4. Melissa

    Atlanta Metro

    28 reviews

    5.0

    28 reviews

    Dined on 11 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Jordan was a delight as a server and guide to all your wonderful dishes. I will miss the roasted beet salad as you are changing menus but look forward to your new menu in January when I return.

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  5. Jeannie

    Denver

    2 reviews

    5.0

    2 reviews

    Dined on 9 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous food. Lovely pottery dishes. Great wait staff! Great bread

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  6. Racheal

    Jacksonville

    5 reviews

    vip
    3.0

    5 reviews

    Dined on 8 November 2024

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    Our server was attentive and kind. Our food took too long to come out from the kitchen. Luckily, our group enjoys spending time with each other.

    Is this helpful?

  7. kayla

    Jacksonville

    1 review

    5.0

    1 review

    Dined on 4 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Brandon and Dwayne were amazing. Brandon made me a fabulous Dirty Martini and Dwayne recommended two very good bottles of wine for the half off wine Monday. Destanee was a great server and also recommended the Summer Truffle Tagliatelle and Steak Frites. Doug and Dalvin also stopped by our table to make sure everything came out good. Chef Thomas prepared an amazing dessert and all the food was awesome.
    M Brothers at MayoResponded on 5 November 2024
    Thank you for the kind words! We're so glad to hear Brandon, Dwayne, Destinee, Doug, Dalvin, and Chef Thomas all made your experience memorable. We’ll be sure to pass along your compliments to the team. Hope to see you again soon!

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  8. Melanie

    Coastal Georgia

    2 reviews

    5.0

    2 reviews

    Dined on 31 October 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The food here is outstanding. I had to stay on the Mayo campus for several days due to a procedure, and it was so uplifting to be able to go to a 4 star restaurant during my recovery process. The atmosphere was very relaxing and beautiful, the service was impeccable, and my entree, the Salmon Nicoise, was delicious. They also have an extensive wine menu, cocktail menu, and delicious desserts.

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  9. max

    Miami

    59 reviews

    vip
    5.0

    59 reviews

    Dined on 22 October 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great staff and food always fresh. Ordered the burrata, shrimp po boy and hamburger they were delicious
    M Brothers at MayoResponded on 23 October 2024
    Thank you for the kind words! Our team looks forward to serving you again soon!

    Is this helpful?

  10. Brandi

    Orlando

    3 reviews

    5.0

    3 reviews

    Dined on 15 October 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Great food, great service. Don’t let the idea of a restaurant located in a hospital put you off. Free valet and staff was friendly and engaging. We’ll be back!
    M Brothers at MayoResponded on 21 October 2024
    Thank you for the great review! We're so glad you enjoyed the food and service. We look forward to welcoming you back soon!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 454 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
19:00
Booked 14 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
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