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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
512 Reviews
$50 and over
Seafood

Make a booking

2 people
21:30
Booked 2 times today
Experiences are available.

About this restaurant

  • Good for business meals
  • Good for special occasions
  • Healthy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

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Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Phone number
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: Florence, Italy

    US$90.00 - US$135.00 per person

    19 Apr 2025 only
    Culinary Passport: Florence, Italy Join us at M Brothers on Saturday, April 19, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the rich culinary traditions of Florence, Italy. From handmade pasta to expertly prepared meats and decadent Tuscan desserts, each dish captures the essence of this iconic region. This experience is priced at $90 per person, or elevate your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on April 19th—don’t miss this unforgettable taste of Florence! 🇮🇹✨

What 512 people are saying

M Brothers at Mayo reviews from people who’ve dined at this restaurant. Based on recent rating.

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.7Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience right on the Mayo Clinic grounds. The food is "outstanding," with dishes beautifully presented, and the ambiance is both relaxing and elegant. Service is "consistently excellent," with staff members like Destiny and Jordan receiving high praise. A "true gem" in a unique setting!
512 Reviews
  1. Nadine

    Jacksonville148 reviews

    3.0

    Dined 5 days ago

    1. Overall 3
    2. Food 2
    3. Service 3
    4. Ambience 5
    I love all the other Medure restaurants, This one misses by a lot. Went here when they first opened and did not have a good experience. Revisited now several years later and it still was a disappointment. First I still question opening a high end restaurant inside a hospital. The food was the big disappointment. All their other Medure restaurants are five star. I have no problem with the limited menu but it seemed like half was Asian influence. The pasta was thick sauced and had no flavor. The chicken (ordered w the pasta) was just ok.. The BEST part was the dessert - the chocolate ganache was to die for. The restaurant design is very upscale and amazing, now they just need a good menu and chef for the high price of the food.

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  2. Marty VIP

    Denver5 reviews

    5.0

    Dined 5 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We held a birthday dinner for nine. It couldn’t have been a better experience. We were seated at the chef’s table. From there half the group could watch the kitchen team at work. Our server KK was excellent. We love the menu…something for everyone from salads to soups to main courses that are varied enough that everyone has her (different) favorite. Our dinners were delicious. We especially appreciated being able to bring in our own birthday cake and have KK serve it. Finally the fact that the noise level is about the lowest of all the restaurants in the area made M Brothers a perfect place to catch up with friends and celebrate special days. We have already booked our next celebration!
    M Brothers at MayoResponded 3 days ago
    Thank you for the fantastic review! We're thrilled to hear your birthday dinner was such a memorable experience. It’s great that you enjoyed the the menu variety and KK's excellent service. We’re also happy to hear that the quieter atmosphere made it the perfect spot to celebrate. We can't wait to host you for your next celebration!

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  3. THOMAS VIP

    Charleston23 reviews

    5.0

    Dined 5 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    This restaurant is clearly a diamond at a world class facility! Not to be missed!
    M Brothers at MayoResponded 3 days ago
    Thank you for the amazing compliment! We're thrilled you had such a great experience and appreciate your kind words. We hope to welcome you back soon!

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  4. Kent VIP

    E. Tennessee2 reviews

    5.0

    Dined 7 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Wonderful experience. All thumbs-up! Wonderful Mayo-campus experience.
    M Brothers at MayoResponded 3 days ago
    Thank you for the wonderful review! We're so glad you had a great experience, and we are proud to be a part of Mayo's campus. Hope to see you again soon!

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  5. Vikki VIP

    Tampa5 reviews

    5.0

    Dined 7 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great service and delicious food! Highly recommend!
    M Brothers at MayoResponded 3 days ago
    Thank you for your kind words! We're so glad you enjoyed the service and food. We appreciate the recommendation and hope to see you again soon!

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  6. OpenTable Diner

    Jacksonville1 review

    5.0

    Dined on 22 March 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Went to the Taste of Peru. This was our 3rd time here. The food is always amazing and wine pairing spot on. Can’t wait until next month.
    M Brothers at MayoResponded 3 days ago
    Thank you for your continued support! We're thrilled to hear you enjoyed the Culinary Passport: Taste of Peru and that the food and wine pairing were on point. We can’t wait to welcome you back next month!

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  7. Elizabeth

    Jacksonville784 reviews

    5.0

    Dined on 19 March 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    I met a friend for lunch at M Brothers at Mayo. We both ordered the BLT, she with fries and I with the side Cesar salad. And we had iced tea to drink. All was delicious and Destiny was an outstanding server. Highly recommended for a relaxing experience in an upscale setting, whether or not you have medical appointments at Mayo.
    M Brothers at MayoResponded on 21 March 2025
    Thank you for your wonderful review! We're thrilled to hear you enjoyed your lunch and that Destanee took great care of you. We’re so glad you had a relaxing experience, and we look forward to welcoming you back soon!

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  8. OpenTable Diner

    Orlando2 reviews

    5.0

    Dined on 15 March 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Our dinner was wonderful! I had the Salmon, my husband had the Sushi Bowl. Both were delicious. He was surprised by the full bar and selections of wine. Who knew such a beautiful restaurant was right on the Mayo Clinic grounds!! They also serve lunch!!
    M Brothers at MayoResponded on 21 March 2025
    Thank you for your lovely review! We love being part of the Mayo Clinic campus and can’t wait to welcome you back for lunch or dinner soon!

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  9. Connie

    Tallahassee2 reviews

    5.0

    Dined on 11 March 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Best waitress and food was exceptionally good! Recommend the bread plate as a starter!
    M Brothers at MayoResponded on 21 March 2025
    Thank you for the wonderful review! We’re so glad to hear you had great service and enjoyed the food. The bread plate is definitely a fan favorite! We look forward to serving you again soon!

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  10. Larry VIP

    Jacksonville17 reviews

    5.0

    Dined on 1 March 2025

    1. Overall 5
    2. Food 4
    3. Service 4
    4. Ambience 5
    Marie welcomed us and seated us promptly. Briana was informative and suggested items. Food and wine was outstanding and ample. Desert was shared to cap off a nice dinner. Valet parking was close by and appreciated.
    M Brothers at MayoResponded on 3 March 2025
    Thank you for the lovely review! We're so glad you had a great experience, from Marie's warm welcome to Briana's helpful suggestions. We hope to welcome you back soon for another outstanding dinner!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.7 stars by 512 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
21:30
Booked 2 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00–14:00 Dinner Mon–Sat 17:00–21:00
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
  • Privacy Policy
  • Terms of Use
  • Impressum
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